PUBLICATIONS

2023

Liu, X., L. Rao, and A. Gennerich. Measurements of the Force-Dependent Detachment Rates of Cytoplasmic Dynein from Microtubules. 2023. Methods Mol. Biol., 2623:221-238. [pdf]

2022

Fu, X*,#, L. Rao*, P. Li, X. Liu, Q. Wang, A. I. Son, A. Gennerich#, and J. S.-H. Liu#. Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking. 2022. eLife, e82218 (*: co-first authors; #: corresponding authors). [pdf]

Rao, L., and A. Gennerich. Single-molecule studies on the motion and force generation of the Kinesin-3 motor KIF1A. 2022. Methods Mol. Biol. 2478:585-608. [pdf]

Pant, D.C.*, J. Parameswaran*, L. Rao L, L. Shi, G. Chilukuri, Z. McEachin, G. Bassell, S. Atienzar-Saez, B. Traynor, J. Glass, A. Gennerich, and J. Jiang. ALS-linked KIF5A exon27 mutant causes neuronal toxicity through gain of function. 2022. EMBO Rep., e54234 (*: co-first authors). [pdf]

Impastato A. C., A. Shemet, N. A. Vepek, G. Saper, H. Hess, L. Rao, A. Gennerich*, and D. Trauner*. Optical Control of Mitosis with a Photoswitchable Eg5 Inhibitor. 2022. Angew Chem Int Ed Engl. 61:e202115846. (*: corresponding authors). [pdf]

2021

Blasius, L. T.*, Y. Yue*, R. Prasad, X. Liu, A. Gennerich, and K. J. Verhey. Separate sequences in the stalk domain regulate autoinhibition and ciliary tip localization of the immotile kinesin-4 KIF7. 2021. J. Cell Sci. 134:jcs258464 (*: co-first authors). [pdf]

Lam, A. J., L. Rao, Y. Anazawa, K. Okada, K. Chiba, S. Niwa, A. Gennerich*, D. W. Nowakowski*, R. J. McKenney*. Human disease mutation within a conserved 310-helix in the KIF1A motor domain reveals a critical role for kinesin function. 2021. Sci. Adv. 7:eabf1002 (*: corresponding authors). [pdf]

Boyle, L., L. Rao, S. Kaur, X. Fan, C. Mebane, L. Hamm, A. Thornton, J. T. Ahrendsen, M. P. Anderson, J. Christodoulou, A. Gennerich, Y. Shen, W. K. Chung. Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A associated neurological disorder. 2021. HGG Advances 100026. [pdf]

Budaitis, B.G.*, S. Jariwala*, L. Rao*, Y. Yue, D. Sept#, K. J. Verhey#, and A. Gennerich#. Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms. 2021. J. Cell Biol. 220:e202004227 (*: co-first authors listed alphabetically; #: corresponding authors). [pdf]

2020

Liu, X., L. Rao, and A. Gennerich. The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein. 2020. Nat. Commun. 11:5952. [pdf]

Brenner, S., F. Berger, L. Rao, M. P. Nicholas, and A. Gennerich. Force production of human cytoplasmic dynein is limited by its processivity. 2020. Sci. Adv. 6:eaaz4295. [pdf]

2019

Rao, L., F. Berger, M. P. Nicholas, and A. Gennerich. Molecular mechanism of cytoplasmic dynein tension sensing. 2019. Nat. Commun. 10:3332. [pdf]

2018

Rao, L., M. Hülsemann, and A. Gennerich. Combining structure-function and single-molecule studies on cytoplasmic dynein. 2018. Methods Mol. Biol., 1665:53-89. [pdf]

2015

Nicholas, M. P., F. Berger, L. Rao, S. Brenner, C. Cho, and A. Gennerich. Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains. 2015. Proc. Natl. Acad. Sci. USA, 12:6371-6376. [pdf]

Nicholas, M. P.*, P. Hook*, S. Brenner, C. Lazar, R. B. Vallee#, and A. Gennerich#. Control of cytoplasmic dynein force production and processivity by its C-terminal domain. 2015. Nat. Commun., 6:6206 (*: Co-first authors; #: corresponding authors). [pdf]

2014

Nicholas, M. P., L. Rao, and A. Gennerich. Covalent immobilization of microtubules on glass surfaces for molecular motor force measurements and other single-molecule assays. 2014. Methods Mol. Biol., 1136:137-169. [pdf]

Nicholas, M. P., L. Rao, and A. Gennerich. An improved optical tweezers assay for measuring the force generation of single kinesin molecules. 2014. Methods Mol. Biol., 1136:171-246. [pdf]

Gennerich, A. Molecular Motors: DNA Takes Control. 2014. Nat. Nanotechnol., 9:11-12 (invited News & Views article). [pdf]

2013

Rao, L.*, E. M. Romes*, M. P. Nicholas, S. Brenner, T. Ashutosh, A. Gennerich#, and K. C. Slep#. The yeast dynein dyn2-pac11 complex is a dynein dimerization/processivity factor: structural and single molecule characterization. 2013. Mol. Biol. Cell, 24:2362-2377 (*: co-first authors; #: corresponding authors). [pdf]

Shih, S.-M., F. Kocabas, B. Engel, A. Gennerich, W. Marshall, and A. Yildiz. Intraflagellar transport drives flagellar surface motility. 2013. eLife, 2:e00744:1-19 [pdf]

2012

Reck-Peterson, S. L., R. D. Vale, and A. Gennerich. "Motile Properties of Cytoplasmic Dynein". In: "Dynein Handbook" (Pan Stanford Publishing). 2012. Editors: Linda Amos and Keiko Hirose. [pdf]

2011

Gennerich, A. and S. L. Reck-Peterson. Probing the force generation and stepping behavior of cytoplasmic dynein. 2011. Methods Mol. Biol., 783:63-80. [pdf]

Huckaba, T., A. Gennerich, J. E. Wilhelm, A. Chishti, and R. D. Vale. Kinesin 73 is a processive motor that localizes to Rab5-containing organelles. 2011. J. Biol. Chem., 286:7457-7467. [pdf]

2009

Gennerich, A. and R. D. Vale. Walking the walk: how kinesin and dynein coordinate their steps. 2009. Curr. Opin. Cell Biol., 21:59-67. [pdf]

2008

Yildiz, A., M. Tomishige, A. Gennerich, and R. D. Vale. Intramolecular strain coordinates kinesin stepping behavior along microtubules. 2008. Cell, 134:1030-1041. [pdf]

2007

Gennerich, A., A. P. Carter, S. L. Reck-Peterson, and R. D. Vale. Force-induced bidirectional stepping of cytoplasmic dynein. 2007. Cell 131:952-965. [pdf]

2006

Imanishi, M., N. F. Endres, A. Gennerich, and R. D. Vale. Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3. 2006. J. Cell Biol. 174:931-937. [pdf]

Reck-Peterson, S. L., A. Yildiz, A. P. Carter, A. Gennerich, N. Zhang, and R. D. Vale. Stepping behavior and structural requirements for cytoplasmic dynein processivity. 2006. Cell 126:335-348. [pdf]

Gennerich, A. and D. Schild. Finite-particle tracking reveals sub-microscopic size changes of mitochondria during transport in mitral cell dendrites. 2006. Phys. Biol. 3:45-53. [pdf]

2005

Gennerich, A. and D. Schild. Sizing-up finite fluorescent particles with nanometer-scale precision by convolution and correlation image analysis. 2005. Eur. Biophys. J. 34:181-99. [pdf]

2003

Czesnik, D., W. Rössler, F. Kirchner, A. Gennerich, and D. Schild. Neuronal representation of odourants in the olfactory bulb of Xenopus laevis tadpoles. 2003. Eur. J. Neurosci. 17:113-118. [pdf]

2002

Gennerich, A. and D. Schild. Anisotropic diffusion in mitral cell dendrites revealed by fluorescence correlation spectroscopy. 2002. Biophys. J. 83:510-522. [pdf]

2000

Peters, F., A. Gennerich, D. Czesnik, and D. Schild. Low frequency voltage clamp: recording of voltage transients at constant average command voltage. 2000. J. Neurosci. Meth. 99:129-135. [pdf]

Gennerich, A. and D. Schild. Fluorescence correlation spectroscopy in small cytosolic compartments depends critically on the diffusion model used. 2000. Biophys. J. 79:3294-3306. [pdf]

1996

Schild, D., A. Gennerich, and H. A. Schultens. 1996. Microcontrollers as inexpensive pulse generators and parallel processors in electrophysiological experiments. Med. Biol. Eng. Comput. 34:305-307. [pdf]